Exosome for the
Most-advanced
Hair Growth

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Hair growth with next-generation regeneration factor

Focusing on the function of the message substance “exosome”
It delivers pharmaceutical-grade active ingredients
to hair matrix cells in order to address
age-related hair problems

What is exosome?

Are you familiar with the substance “exosome” that has been attracting attention in the beauty industry in recent years?
Exosomes are a substance that exist in our bodies and carry “messages” to our cells.

It is said that by including particles of these exosomes in cosmetics and hair growth agents, messages can be delivered more reliably.

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“Exocomplex Premium Growth”
focusing on the power of exosomes

“Exocomplex Premium Growth” was created with a focus on the function of particles of these exosomes.
By making full use of cutting-edge research results and technologies, this hair growth lotion has been successfully made with a high content of exosomes.

The pharmaceutical-grade “stem cell culture supernatant” contained in Exocomplex Premium Growth can be delivered more effectively to the hair matrix cells by the function of the exosome particles.
This item is recommended for those who are concerned about age-related thinning hair, hair loss, fine hair, loss of hair strength and gloss, damaged hair, etc.

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What is stem cell culture supernatant?

Stem cell culture supernatant is a supernatant liquid obtained by culturing stem cells from dental pulp, umbilical cords, fat, etc., which exist in the human body, and extracting stem cells from the culture fluid.
It is expected to have the effect of delaying the decline of skin and hair due to aging.

What is stem cell culture supernatant?
Provided by: AZFREYA INC.

Features of “Exocomplex Premium Growth”

Mixture of three types of mesenchymal stem cell culture supernatants

The stem cell culture supernatant contained in Exocomplex Premium Growth is a mixture of three types, each with different purposes and targets. By using ingredients derived from dental pulp, fat and umbilical cords, it is expected to have the effect of growing hair while supporting a variety of functions.

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Dental pulp-derived
stem cell
culture supernatant

Target: Skin

Stem cells taken from nerve tissues in the center of teeth are cultured

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Umbilical cord-derived
stem cell
culture supernatant

Target: Tissue repair

Stem cells obtained from umbilical cords are cultured

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Adipose tissue-derived
stem cell
culture supernatant

Target: Hair

Stem cells of adipose tissues taken from abdomen, etc. are cultured

High content of exosome particles

We have succeeded in making the stem cell culture supernatant contained in Exocomplex Premium Growth have a high content of exosomes, a message substance, using our unique technology. Exosomes reliably deliver the ingredients not only to neighboring cells but also to distant cells.

“PLAG Nanocapsules,”
12-hour sustained penetration capsules

We have nano-encapsulated stem cell culture supernatants with “PLAG Nanocapsules.” As the capsule releases beauty ingredients for 12 hours, a sustained penetration effect can be expected. By reducing the ingredient size to the nano level, the ingredients are able to reach hair matrix cells without fail.

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Commitment to manufacturing

Manufacturing
facilities

As a specified processed cell manufacturer, we manufacture culture supernatants in strictly controlled facilities.

Donors used

We select raw materials only from Japanese donors.

Cells used

We have confirmed that the cells used to manufacture culture supernatants express surface markers of mesenchymal stem cells. These mesenchymal stem cells are only used for manufacturing culture supernatants in better condition, and the cells are discarded after the supernatants are collected.

Safety tests

Tests such as endotoxin, general bacteria/fungi, mycoplasma, and various virus tests have been performed, and the results have been confirmed to be negative.

Hair growth effect

Widening parting (37-year-old female)

Application in morning and evening for 12 days

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AGA male pattern baldness (44-year-old male)

Treatment once a week for a total of 7 times, then continuing to use once a month

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*The progress of hair growth varies from person to person, depending on the individual’s age, lifestyle, and scalp condition.

Images provided by AZFREYA INC.

Introduction into hair matric cells by electroporation

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Introduction into hair matric cells by electroporation

Exocomplex Premium Growth’s “PLGA nanocapsules” break down ingredients to the nano level so that they can penetrate the stratum corneum and reach the targeted area without fail.

“Furthermore, electroporation is expected to have higher effects when used in salons. This is because ingredients can be delivered to hair matrix cells more quickly and reliably by using technologies such as electroporation and EMS on a clean scalp after removing sebum dirt at the salon.”

The stratum corneum exists on the surface of the skin. While the stratum corneum prevents foreign substances from entering the skin, it can also prevent ingredients from penetrating cells when a serum or other beauty product is applied. By using electroporation, minute holes can be made in the cell membrane of the scalp, temporarily forming a permeation pathway in the cells and allowing ingredients to be delivered into the cells. Its action is said to be “tens to hundreds of times more effective” than simple application.

In our treatment, radio waves (high frequency) and electroporation/EMS (low/medium frequency) are simultaneously output to deliver the ingredients contained in Exocomplex Premium Growth. Furthermore, EMS is used to spread the penetrated serum into every corner of the skin.

Effects of electroporation

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Penetration pathway

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